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N2 – recent reports of the dramatic antitumour effect of tretinoin all-trans retinoic acid in patients with acute promyelocytic leukaemia apl have generated a great deal of interest in the use of this drug as a chemopreventive and therapeutic agent.

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the isotretinoin reduces the oil production, it makes the top layer of the skin less sticky and it has got an anti-inflammatory action.

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tretinoin is a retinoid and the carboxylic acid form of vitamin a.

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must be registered with the ipledge program by the prescriber must understand that severe birth defects can occur with the use of isotretinoin by female patients must be reliable in understanding and carrying out instructions must sign a patient information informed consent for all patients form that contains warnings about the potential risks associated with isotretinoin must fill and pick up the prescription within 7 days of the date of specimen collection for the pregnancy test for female patients of childbearing potential must fill and pick up the prescription within 30 days of the office visit for male patients and female patients not of childbearing potential must not donate blood while on isotretinoin and for 1 month after treatment has ended must not share isotretinoin with anyone, even someone who has similar symptoms.

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tretinoin cream or tretinoin gel should be applied once a day, before retiring, to the skin where acne lesions appear, using enough to cover the entire affected area lightly.

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the manufacturer does not recommend long-term use of isotretinoin.

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