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the methods include a measuring a level of serpina-1 polypeptide and or albumin polypeptide in a first sample obtained from the pregnant woman; and b measuring a level of serpina-1 polypeptide and or albumin polypeptide in a second sample obtained from the same pregnant woman, wherein the second sample is obtained at a time subsequent to the time the first sample is obtained, wherein an increase in the serpina-1 polypeptide and or albumin polypeptide level in the second sample relative to the serpina-1 polypeptide and or albumin polypeptide level in the first sample identifies onset or progression of preeclampsia in the subject and a decrease in the serpina-1 polypeptide and or albumin polypeptide level in the second sample relative to the serpina-1 polypeptide and or albumin polypeptide level in the first sample identifies regression of preeclampsia in the subject.

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