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In addition, among contacts with a positive tuberculin skin test, for every 35 patients treated with isoniazid for six months, one case of active tb will be prevented smieja et al.

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do not take this medicine with any of the following medications -certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole -cisapride -dofetilide -dronedarone -escitalopram -linezolid -maois like carbex, eldepryl, marplan, nardil, and parnate -methylene blue injected into a vein -pimozide -thioridazine -ziprasidone this medicine may also interact with the following medications -alcohol -amphetamines -aspirin and aspirin-like medicines -carbamazepine -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for infections like chloroquine, clarithromycin, erythromycin, furazolidone, isoniazid, pentamidine -certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan -certain medicines for sleep -certain medicines that treat or prevent blood clots like dalteparin, enoxaparin, warfarin -cimetidine -diuretics -fentanyl -lithium -methadone -metoprolol -nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -omeprazole -other medicines that prolong the qt interval cause an abnormal heart rhythm -procarbazine -rasagiline -supplements like st.

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because there is a higher frequency of isoniazid associated hepatitis among certain patient groups, including age greater than 35, daily users of alcohol, chronic liver disease, injection drug use and women belonging to minority groups, particularly in the post-partum period, transaminase measurements should be obtained prior to starting and monthly during preventative therapy or more frequently as needed.

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mutations in other genes, such as ahpc and ndh , have been implicated in isoniazid resistance, but their roles are not yet proven.

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