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The worldwide interest in the 1950s in nicotinamide isoniazid analogues for the treatment of tb led to other agents, including pyrazinamide and ethionamide, both of which are still used in some combination-treatment regimens greenwood, 2008 .

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when a single 250-mg oral dose of ethionamide is given as sugar-coated tablets trecator-sc; no longer commercially available in the us in healthy adults, peak plasma concentrations average 1.

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