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Febuxostat, a nonpurine inhibitor of xanthine oxidase, could be used for treatment in those patients with allopurinol hypersensitivity, intolerance, or treatment failure.

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in patients with impaired renal function in long-term treatment 200-400 mg allopurinol per day noted the development of skin reactions, eosinophilia, hepatitis, hyperthermia and acute kidney disease.

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